CONCLUSION
In this context, thyroid hormone critical role on memory has been expatiated from a peripheral to the intrinsic point of view. Thyroid hormone plays a wide and sensitive role in memory mechanism in the brain.
Thyroid hormone is mainly involve in the generalized brain development. Hippocampus which is the brain memory box depends on the thyroid hormone for morphological growth and development by acting on subgranular zone in the hippocampus. TRa1 is the most predominant receptor found in the region 1 proper of the hippocampus. To be precised, many mechanism has been elicited by thyroid hormone on maintenance, modulation and enhancement of memory.
This include; hippocampal glucose regulation as a gluconeogenic hormone, increasing hippocampal and cortical serotonin release, modulation of GABA release and its receptors and finally by negatively regulating amyloid beta precursor protein.
Conglomeration of all this function initiated by thyroid hormone on brain and memory, it is obvious that thyroid gland impairment (hyperthyroidism or hypothyroidism) affects memory or brain in general.
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Research done by Anyanwu Ifeanyi Hippolyte
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